ObjectiveTo investigate knowledge, attitude and behavior about acquired immunodeficiency syndrome （AIDS） among normal and nonnormal school students in Huanggang City, and provide basis for making policies on health education about AIDS knowledge among college students.Methods220 normal school students and 250 nonnormal school students were randomly selected as studied subjects, a questionnaire survey was conducted among them,and the surveyed results were compared.ResultsThe average score of general knowledge related to AIDS and attitude toward AIDS patients was 77.61% and 87.35% in normal school students,  69.15% and 79.14% in nonnormal school students respectively,  there were significant difference between them(u=2.03，P<0.05；u=2.34，P<0.05); the average score on related knowledge about AIDS transmission routes and attitude toward AIDS was 82.80% and 92.99% in normal school students,  76.50% and 89.84% in nonnormal school students respectively,  there were no significant difference between them(both P＞0.05).ConclusionIt is necessary and important to develop AIDS health education among college students.