This article reports thediagnosis and treatment process of a case with secondary infective femoral artery pseudoaneurysm after intervention surgery for cerebral infarction, who improved after anti-infection and surgical treatment and was discharged. The patient was a 52-year-old female who underwent percutaneous balloon dilatation of basilar artery due to basilar artery stenosis. After surgery, she developed secondary methicillin-resistant Staphylococcus aureus (MRSA) bloodstream infection and infective femoral artery pseudoaneurysm. After treatment with vancomycin and linezolid, femoral artery pseudoaneurysm resection, and autovascular replacement, the patient recovered well after the surgery and discharged from hospital. CT angiography (CTA) re-examination showed artificial blood vessel patency. This study is expected to provide experience for the diagnosis and treatment of such patients in clinical work.