The prevalence of antimicrobial resistance (AMR) remains a critical global health threat. The World Health Organization (WHO) released the Global Antibiotic Resistance Surveillance Report 2025, this report evaluates the resistance landscape of 8 priority pathogens and 22 antimicrobial agents across four categories of clinical infections. Utilizing data from over 23 million bacteriologically confirmed infections across 104 countries, the report employs a Bayesian hierarchical model for assessment and introduces a surveillance system maturity scoring framework to address data disparities. Findings indicate a persistent upward trend in resistance in key pathogens, particularly among Gram-negative bacteria, posing increasingly severe challenges to first-line treatments for bloodstream, urinary tract, and gastrointestinal infections. Low-income countries face heightened AMR risks due to deficiencies in surveillance and diagnostic capacities. This interpretative summary outlines the core findings of the report, providing an evidence-based foundation for precision prevention and control strategies, as well as the optimization of empirical antimicrobial therapy.