北京市西城区连续6年诺如病毒疫情流行特征及基因分型分析
作者:
作者单位:

作者简介:

通讯作者:

中图分类号:

R181.3

基金项目:


Epidemiological characteristics of epidemics and genotyping of norovirus in Xicheng District of Beijing for 6 consecutive years
Author:
Affiliation:

Fund Project:

  • 摘要
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 文章评论
    摘要:

    目的 分析北京市西城区诺如病毒(NoV)胃肠炎疫情的流行特征及基因型分布,为预防和控制NoV胃肠炎疫情提供科学依据。方法 采用描述性流行病学方法对2019年7月—2025年6月北京市西城区NoV胃肠炎疫情资料进行分析。应用逆转录聚合酶链式反应(RT-PCR)进行GⅠ型和GⅡ型NoV核酸检测,核酸阳性标本送至北京市疾病预防控制中心进行序列测定和基因分型鉴定。结果 共报告NoV胃肠炎疫情179起,其中聚集性疫情168起(93.85%),暴发疫情11起(6.15%),涉及病例1 744例,总罹患率为11.04%。疫情总体呈波动趋势,且隔年高发。每年疫情高峰集中于秋季开学后10—12月和春季开学后3—5月,具有明显季节性。小学为最主要的疫情发生场所(85起,47.48%),其次为学前机构(61起,34.08%)。GⅡ型NoV是引起疫情的主要病原体(占疫情总数的85.47%)。基因分型显示:2019年7月—2021年6月以GII.2[P16]为优势基因型;2021年7月—2022年6月仅1起疫情鉴定成功;2022年7月—2024年6月呈多基因型共流行,无明显优势型别;2024年7月—2025年6月GII.17[P17]成为新的优势基因型。结论 北京市西城区NoV胃肠炎疫情主要集中于小学及学前机构,秋冬季和春季高发。提示应在开学季加强各项防控措施,同时持续开展疫情及散发病例的病原学监测,密切追踪病毒变异动态,为疫情精准防控提供科学依据。

    Abstract:

    Objective To analyze the epidemiological characteristics and genotype distribution of norovirus (NoV) gastroenteritis epidemics in Xicheng District of Beijing, and to provide scientific basis for the prevention and control of NoV gastroenteritis epidemics. Methods Descriptive epidemiological method was adopted to analyze the data of NoV gastroenteritis epidemics in Xicheng District of Beijing from July 2019 to June 2025. Reverse transcription polymerase chain reaction (RT-PCR) was used for GⅠ and GⅡ NoV nucleic acid testing. Nucleic acid positive specimens were submitted to the Beijing Center for Disease Prevention and Control for sequencing and genotyping identification. Results A total of 179 NoV gastroenteritis epidemics were reported, including 168 clustered epidemics (93.85%) and 11 outbreaks (6.15%), involving 1 744 cases, with an overall attack rate of 11.04%. The epidemics presented an overall fluctuating trend, characterized by biennial peak. Annual peak of the epidemic concentrated in October-December following the start of autumn semester and in March-May following the start of spring semester, with distinct seasonality. Primary schools were the most common settings where the epidemic occurred (n=85, 47.48%), followed by preschool institutions (n=61, 34.08%). GⅡ NoV was the main pathogen causing the epidemics (accounting for 85.47% of the total epidemics). Genotyping showed that GII. 2 [P16] was the dominant genotype from July 2019 to June 2021; only 1 epidemic was successfully identified from July 2021 to June 2022; there was a multi-genotype co-epidemic with no obvious dominant type from July 2022 to June 2024; GII.17 [P17] emerged as a new dominant genotype from July 2024 to June 2025. Conclusion NoV gastroenteritis epidemics in Xicheng District of Beijing are mainly concentrated in primary schools and preschool institutions, with high incidence in autumn, winter and spring. It is suggested to strengthen various prevention and control measures during the school opening seasons, continuously conducting pathogen monitoring of the epidemics and sporadic cases, closely tracking the dynamics of virus mutation, and providing scientific basis for precise epidemic prevention and control.

    参考文献
    相似文献
引用本文

黄艳红,初艳慧,刘潇潇,等.北京市西城区连续6年诺如病毒疫情流行特征及基因分型分析[J]. 中国感染控制杂志,2026,25(7):987-993. DOI:10.12138/j. issn.1671-9638.20264399.
HUANG Yanhong, CHU Yanhui, LIU Xiaoxiao, et al. Epidemiological characteristics of epidemics and genotyping of norovirus in Xicheng District of Beijing for 6 consecutive years[J]. Chin J Infect Control, 2026,25(7):987-993. DOI:10.12138/j. issn.1671-9638.20264399.

复制
分享
文章指标
  • 摘要阅读次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:2026-04-08
  • 最后修改日期:
  • 录用日期:
  • 在线发布日期: 2026-07-27
  • 出版日期: 2026-07-28